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The changes in level of discomfort as assessed by the SFNSL after 4 mg ARA 290 administered subcutaneously daily was remarkably similar to what was observed in the previous blinded trial, in which 2 mg ARA 290 was administered three times weekly by the IV route (20)

Both acquisitions are performed in full-scan MS1 mode with data-dependent MS2 fragmentation triggered for the top-N precursors providing both coverage depth and structural identification capacity from a single injection per mode

In other embodiments, the formulations or compositions described herein are stable with respect to compound degradation over a period of at least about 1 week

Abbreviations mCRPC, metastatic castration-resistant prostate cancer